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Histotechnologist

Nudge· Research
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San FranciscoFull-timePosted 6mo ago

About the role

Histotechnologist to own and execute histology workflows at Nudge, focusing on mouse and rat brain tissue, building the full histology pipeline from perfusion to imaging to support ultrasonic neuromodulation research.

Responsibilities

  • Perform routine and advanced histological processing of rodent brain tissue, including perfusion, prosection, fixation, embedding (paraffin and OCT), and sectioning via microtome, cryostat, and vibratome
  • Execute standard histological stains (H&E, special stains) and immunohistochemistry using both manual and automated staining platforms
  • Operate and optimize tissue clearing platforms (electrophoretic, solvent-based) for whole-brain and thick-section imaging
  • Prepare cleared tissue for light sheet fluorescence microscopy and volumetric 3D imaging
  • Operate and maintain automated sectioning and tissue processing systems
  • Prepare and process samples for spatial omics platforms, including multiplexed protein imaging and spatial transcriptomics, with both RNA- and protein-based tagging approaches
  • Develop, optimize, and document SOPs for histological workflows, ensuring reproducibility and quality
  • Collaborate with research scientists to adapt tissue processing and staining strategies to specific experimental questions

Qualifications

  • Hands-on experience in histotechnology, with significant time spent processing rodent brain tissue
  • Proficiency across core histological techniques: microtomy (paraffin, cryo, vibratome), tissue embedding, H&E staining, and immunohistochemistry
  • Experience with at least one tissue clearing method and associated imaging modalities (light sheet microscopy)
  • Familiarity with automated staining and sectioning platforms
  • HT(ASCP) certification or equivalent training; Bachelor’s degree in biology, neuroscience, or a related field preferred
  • High integrity and strong professional judgment

Skills

Required:HistotechnologyTissue clearingAutomated staining and sectioning
Last updated Aug 13, 2026. Interested? Apply on the company site.
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Whole-brain interfaces for everyday life

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