Senior Scientist, Analytical Chemistry
Hybrid (Cambridge, MA)$150k - $180kFull-timePosted 5mo ago
About the role
Role focused on analytical characterization and formulation of oligonucleotides to support Deep Genomics research, including ensuring identity and purity of oligos from external CROs and during pre-clinical metabolism studies, with responsibilities for formulation, sample tracking, and building an internal analytics lab.
Responsibilities
- Maintain efficient workflows for analytical characterization of DG oligos at CROs.
- Working with the leader of Molecular Design Chemistry, develop and implement a potential, future plan for the installation of an LCMS system for analysis of oligonucleotides.
- Act as DG KOL for characterization of oligonucleotides in terms of identify, purity, and stability.
- Develop analytical methods for the future LCMS system to characterize research oligonucleotide samples including characterization of chemical and metabolic stability.
- Generate Certificate of Analysis reports from such data.
- Perform formulation processes to provide research samples ready for in vitro and in vivo experimentation including endotoxin analysis.
- Develop and maintain a sample tracking system for the compounds that come into Deep Genomics at Cambridge.
- Future responsibilities may include bioanalysis of PK samples.
Qualifications
- PhD in analytical, pharmaceutical sciences, or bio-organic chemistry including expertise in HPLC and mass spectrometry with 2 years experience; MS in similar fields with +5 years experience.
- Excellent communication skills coupled with good collaboration style.
- Experience in the laboratory techniques for oligonucleotides.
- Experience in designing and implementing new processes for oligonucleotide samples.
Skills
Required:HPLCMass spectrometryOligonucleotide analyticsProcess designCommunication & collaboration
Benefits
- A collaborative and innovative environment at the frontier of computational biology, machine learning, and drug discovery.
- Highly competitive compensation, including meaningful stock ownership.
- Comprehensive benefits - including health, vision, and dental coverage for employees and families, employee and family assistance program.
- Flexible work environment - including flexible hours, extended long weekends, holiday shutdown, unlimited personal days.
- Maternity and parental leave top-up coverage, as well as new parent paid time off.
- Focus on learning and growth for all employees - learning and development budget & lunch and learns.
Last updated Sep 2, 2026. Interested? Apply on the company site.
About Deep Genomics
Programming RNA Therapies Any Gene, Any Genetic condition
Revolutions in AI, biology and automation are enabling a new approach to medicine. Deep Genomics is at the forefront.
AI PlatformRNA biologydrug developmentgenetic conditions
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