Founding Senior Scientist, Chemoproteomics / Surfaceomics
Cambridge, MA$130k - $160kFull-timePosted 4mo ago
About the role
Founding senior scientist to develop, optimize, and automate chemoproteomics and surfaceomics workflows for a mass-spectrometry–based internalization platform; contribute to open science, data analysis pipelines, and long-term surfaceomics discovery strategies in a startup/academic-cellow collaboration.
Responsibilities
- Develop and optimize on-cell surface labeling workflows for MS-based internalization profiling (WGA-HRP and NHS-SS-biotin);
- Execute time-course internalization experiments with pulse-chase labeling, surface-label removal, sample prep, MS, and quantitative analysis;
- Collaborate on glycoprotein enrichment platform with MS colleagues;
- Drive development of photocatalytic cell-surface labeling for frozen/ fixed human tissues;
- Contribute to reproducible computational pipelines for proteomics quantification and AI-ready atlas data integration;
- Document experimental methods, instrument performance, and QC metrics across batches;
- Co-author open-access blog posts, open protocols, publications/white papers;
- Shape long-term strategy for surfaceomics discovery and validation;
- Lead platform development and potentially manage external CRO partnerships as the organization evolves;
- Mentor and collaborate across disciplines to generate high-quality, AI-ready datasets;
- Support open science by publishing work and enabling broad use by researchers and drug developers.
Qualifications
- PhD in proteomics, chemical biology, biochemistry, cell biology, or related field with 2-8 years of postdoc experience (industry preferred);
- Hands-on MS acquisition and analysis experience; proficiency with Spectronaut, DIA-NN, or equivalent; experience with downstream statistics and cross-cohort normalization;
- Expertise in high-throughput enrichment proteomics sample prep workflows and automation; knowledge of controls for large cohorts and plate-based preps;
- Strong cell culture skills and willingness to work hands-on at bench;
- Proven ability to independently develop, optimize, and troubleshoot MS workflows; not just execute protocols.
Skills
Required:Mass spectrometry (MS)DIA-MS analysisHigh-throughput enrichment proteomicsCell culture
Nice to have:Data analysis / statistics
Benefits
- Competitive salary and bonus benchmarked to industry rates
- Full health, dental, and retirement benefits
- Founding team role with platform-shaping impact
- Open science by design with published work
- Access to advisors, partners, and collaborators across proteomics, genomics, targeted delivery, and AI
- Culture of rigor, transparency, and speed
Last updated Jul 17, 2026. Interested? Apply on the company site.
About Deliverome Project
Targeted delivery has a bottleneck.
The Deliverome Project is building an open atlas of the human surfaceome — abundance, specificity, internalization, and routing — to scale targeted delivery beyond the liver.
open atlas of the human surfaceomereceptorsdeliverytargeted deliverysurfaceomeADC targetsinternalizationrouting
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