Founding Scientist (Synthetic Genomics)
About the role
Founding scientist role at Exonic, an AI-native cell and gene therapeutics company, focusing on wet-lab execution to validate AI-designed regulatory DNA and advance cell-type targeting and AAV manufacturing.
Responsibilities
- Own and execute experimental validation of AI-designed regulatory DNA
- Design and run cell-based assays for synthetic enhancer and expression systems
- Help advance programs in cell-type targeting and AAV manufacturing
- Help shape Exonic’s experimental roadmap as the company grows
Qualifications
- Molecular biology, synthetic biology, regulatory genomics, or gene therapy
- Mammalian cell culture and cell-based assays
- Cloning, plasmid design, transfection, qPCR/ddPCR, sequencing, flow, luciferase, or related workflows
- AAV biology/manufacturing experience is a major plus
Skills
About Exonic
Unsupervised Biological AI
What if you could train a biological foundation model on... the entire internet? Exonic is pioneering a new generation of biological foundation models, focused on heterogeneous, unstructured, and noisy datasets. Our first application is the design of safer gene therapies. In 2025, we used AI to set a new state of the art in liver cancer targeted gene therapy, validated in vitro in our lab in San Francisco. So far in 2026, we have trained a new model with unprecedented zero-shot generalization on genomic regulatory expression in hold-out biosample datasets. More to be shared soon.