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Director, Clinical Pharmacology

relationrx· Discovery
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LondonFull-timePosted 2mo ago

About the role

Director level role leading clinical pharmacology and pharmacometrics to drive end-to-end asset development across multiple modalities and disease areas, with emphasis on Model-Informed Drug Development (MIDD) and integration of non-clinical and clinical data within Relation’s translational portfolio.

Responsibilities

  • Build and own the clinical pharmacology and pharmacometric capability to support Relation's product development goals, setting standards for excellence and championing innovative approaches to drive data-informed decisions.
  • Act as the Clinical Pharmacology lead for multiple concurrent programmes across indications and therapeutic modalities. Oversee clinical pharmacology input into study design across development, focusing on IND-enabling and Phase 1 trials, advancing to Phase 2 and 3.
  • Work across Translational Safety, Translational Pharmacology and Biomarkers to integrate nonclinical and clinical data, continuously improving predictive accuracy.
  • Lead modelling and simulation approaches, non-clinical to clinical PK/PD, DDI risk assessment, PBPK, population PK/PD and QSP to characterize developability and exposure–response, support dose/ regimen decisions.
  • Lead and manage external collaborations and CRO partnerships with clear prioritisation and timely delivery.
  • Author relevant sections of regulatory documents (Investigator's Brochures, INDs, NDA/BLA/MAA) as clinical pharmacology expert in regulatory interactions.
  • Proactively identify and incorporate emerging AI-enabled approaches into clinical pharmacology workflows.
  • Interface with cross-functional teams to embed clinical pharmacology considerations in development plans.
  • Translate quantitative and biology data into actionable insights for project teams and senior stakeholders.
  • Maintain rigorous documentation across modelling packages, protocols, and study reports.
  • Champion Relation's collaborative, ambitious, science-driven culture and share quantitative expertise across the team.

Qualifications

  • A PhD, PharmD, or MD with specialization in DMPK, Pharmacometrics, in vivo/Clinical Pharmacology, or related field, or equivalent lead industry experience.
  • Significant experience in Quantitative Clinical Pharmacology across all development stages, with strong understanding of drug discovery, non-clinical and clinical development and MIDD principles.
  • Experience across therapeutic modalities (small molecules, biologics, novel platforms).
  • Strong foundation in in vivo Pharmacology and Clinical Pharmacology, with proficiency in pharmacometric tools (NONMEM, R, Monolix, WinNonlin, GastroPlus, SimCyp), data analytics, and AI-enabled approaches; understanding of regulatory landscape and data integration.
  • Outstanding communication skills to translate quantitative data into strategic messages for cross-functional teams and leadership.

Skills

Required:Clinical pharmacology and pharmacometrics leadershipModel-Informed Drug Development (MIDD)Pharmacometric modelling toolsRegulatory documentationCross-functional collaboration
Last updated Aug 26, 2026. Interested? Apply on the company site.

About relationrx

Discovering biology’s relationships, curing disease.

Discovering biology’s relationships, curing disease.

biotechmedicinebiologydiseasegenomicstherapy
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