Analytical Scientist I
Emeryville, CA$120k - $140kFull-timePosted 1mo ago
About the role
Analytical Scientist I to quantify and characterize broad classes of therapeutic proteins, collaborating with R&D and Bioprocess teams to develop and validate protein quality assays and characterize protein products from cell culture processes.
Responsibilities
- Collaborate with cell line development and bioprocess teams for delivery of key internal technology programs and external customer projects.
- Develop, optimize, and validate assays for protein titer and quality for broad classes of recombinant therapeutic proteins.
- Plan and execute experimentation to understand protein quality through cell line, upstream and downstream process development.
- Execute, summarize, interpret, and present routine and complex therapeutic protein characterizations.
- Qualify and validate analytical procedures to compliance standards, upholding rigorous standards for execution and documentation.
- Routinely operate, maintain, and troubleshoot analytical instrumentation (HPLCs, FPLCs, mass spectrometers).
- Author, review, and implement methods, protocols, validations, and standard operating procedures. Ensure processes are followed in accordance with these standards.
Qualifications
- Hold a PhD in Analytical Chemistry, Molecular Biology, Biochemistry, Pharmaceutical Sciences, with 1+ years of biologics industry experience. Candidates without a PhD but with similar industry experience are encouraged to apply.
- Experience in therapeutic protein characterization approaches (eg. HPLC, SDS, CE, cIEF, LC-MS).
- Ability to develop, execute, and interpret intact mass, sequence confirmation, and PTM analysis (e.g., glycosylation, disulfide mapping, peptide mapping) through mass spectrometry.
- Ability to develop, execute, and interpret aggregation and charge variant characterizations for biologics.
- Experience in the development and execution of GLP-compliant methods characterizing protein quality attributes across a wide range of therapeutic classes.
- Hands-on experience operating LC-MS. Experience with Agilent QTOF instrumentation applied to assay protein quality is a plus, including familiarity with proteomic software.
- Strong motivation to deliver successful outcomes for internal and external clients.
- Excellent communication skills and ability to teach/share knowledge across technical levels.
Skills
Required:HPLCSDSCEcIEFLC-MSGlycosylation analysisDisulfide mappingPeptide mapping
Benefits
- Generous equity package in an early stage company
- retirement plan with company contribution
- flexible PTO with healthy time off minimums
- company-covered medical, dental, and vision insurance
- life and disability insurance
- career coaching
- mental health support
- free team lunches everyday
- great snacks
- companywide social events
Last updated Oct 21, 2026. Interested? Apply on the company site.
About Prolific Machines
Illuminating biomanufacturing. Enabling tomorrow’s biotherapeutics.
Difficult protein production made simple. A next-generation expression system for next-generation therapeutics.
protein productionbiotherapeuticscell line developmentbiomanufacturingoptogeneticsAI-driven bioprocess optimization
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