Associate Scientist/Engineer II Technology, Development and Operations - Chemistry
Prime Medicine· Technical Development & Operations
Cambridge, MA$80k - $90kfull-timePosted 1w ago
About the role
Associate Scientist/Engineer II to support RNA chemistry process development, optimization, and tech transfer of a manufacturing process for Prime Editing. Hands-on role at the intersection of chemistry, biology, cell/bioprocessing, bioengineering, and clinical manufacturing, collaborating across R&D, manufacturing, QA, and external partners.
Responsibilities
- Perform routine and non-routine responsibilities for solid-phase chemical synthesis of long guide RNA and downstream purification including chromatography, TFF and lyophilization at different scales using various state-of-the-art laboratory equipment
- Work together with team members to discuss technical and analytical findings and incorporate into the process design for manufacturing implementation
- Conduct hands-on manufacturing of IND-enabling and GLP/GMP RNA guides to support various Prime Editing programs as part of the chemistry team
- Author technical reports, standard operating procedures, draft batch records, and sections for regulatory submissions
- Organize and present experimental data in both written and oral format at the cross-functional team meetings
- Maintain various lab instruments such as ÄKTA synthesizers, AKTA purifiers, preparative scale HPLC, TFF skids, etc, in good operational conditions
- Be willing to take accountability for helping the team to ensure goals and deliverables are achieved, and functional needs are met by carrying out all experiments and completing all technical reports in a timely manner
- Apply AI tools in CMC work to make processes better, faster, and cheaper
- Support new technology evaluations with emphasis on product quality, productivity and/or process robustness
- Keep meticulous experimental records in an electronic lab notebook
- Critically evaluate experimental data and communicate scientific findings in oral presentations and written reports, including protocols, and technical reports in team settings, and at company R&D meetings
Qualifications
- BS or MS in biotechnology, engineering, chemistry, biochemistry, or related life science discipline with ideally 3+ years (BS) or 1+ years (MS) of relevant industry experience in biotech/biopharma
- Experience in chemistry process development of complex biomolecules; experience in oligonucleotide synthesis or downstream purification is a plus
- Fast learner with ability to understand process development unit operations from first principles and to set up and run equipment and instrumentation; prior hands-on experience with equipment and unit operations typically used in process development and manufacture of RNA is preferred
- Experience working in a GMP manufacturing environment, including equipment qualification, investigation and troubleshooting, and operations
- Prior experience developing and writing standard operating procedures and draft batch records is a plus
- Working knowledge of statistical software (e.g., JMP) for process analysis, and data visualization
- Strong written and verbal communication skills
- Able to manage time effectively and escalate relevant issues to other team members and team lead and/or manager
- Highly self-motivated, driven, with a can-do attitude and ability to reliably meet and exceed expectations
- Capable of continuous learning, open-minded, curious, highly organized, and detail-oriented
- Able to work both independently and collaboratively in a fast-paced, dynamic, entrepreneurial, and team-based setting; passionate about helping patients
Skills
Required:Solid-phase chemical synthesis of long guide RNAIND-enabling and GLP/GMP RNA guide manufacturingTechnical report writing and SOP/draft batch recordsData presentation and communication
Nice to have:Lab instrument maintenance (ÄKTA, HPLC, TFF, etc)AI tools in CMC
Benefits
- Total Rewards package with medical, dental, vision, life insurance
- 401(k) with match
- equity programs
- paid time off, wellness days, and company-wide recharge breaks
Last updated Oct 14, 2026. Interested? Apply on the company site.
About Prime Medicine
Delivering on the promise of Prime Editing
Prime Medicine™ was founded with a goal of transforming the lives of patients with debilitating diseases through the application of our groundbreaking Prime Editing platform and technology.
next- generation gene editingPrime Editinggene editingtherapeutic applications
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