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Scientist, Biophysical Characterization (SPR/BLI)

Medra· Science
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San FranciscoFull-timePosted 2mo ago

About the role

Scientist to own biophysical characterization on the Medra Physical AI platform, developing, validating, and scaling label-free binding assays (SPR/BLI) into robust, high-throughput autonomous workflows for antibody and binder characterization.

Responsibilities

  • Develop, validate, and run SPR and BLI assays across formats — affinity and kinetics, epitope binning, self-interaction (AC-SINS and BLI-based), and concentration/quantitation — on Carterra LSA and Gator BLI
  • Design assay strategies for antibody and alternative binder characterization, selecting sensor chemistry, capture approach, regeneration conditions, and analysis models
  • Build out new biophysical capabilities end-to-end: scope need, evaluate technologies, qualify instruments, write SOPs, and prepare validated workflows for autonomous execution
  • Partner with roboticists and software engineers to translate manual SPR/BLI workflows into reliable, high-throughput autonomous protocols
  • Develop rigorous data analysis and QC frameworks for kinetics fitting, binning heatmaps, and developability flags
  • Integrate biophysical data with orthogonal characterization (thermal stability, aggregation/monomericity, polyspecificity) for an integrated developability picture
  • Work directly with customers to scope campaigns, communicate results, and turn scientific questions into executable assay plans
  • Maintain rigorous experimental records in ELN and drive reproducibility across assays

Qualifications

  • Ph.D. in biochemistry, biophysics, structural biology, or related field with 2+ years industry experience, or a B.S./M.S. with 6+ years hands-on industry experience
  • Deep hands-on expertise with SPR and/or BLI — instrument operation, assay development, and data analysis
  • Strong command of binding kinetics theory and practical pitfalls (avidity, mass transport, regeneration, surface capacity, fitting models)
  • Experience developing and qualifying biophysical assays from scratch, including method validation and troubleshooting
  • Working understanding of antibody structure, function, and therapeutic antibody discovery/developability
  • Strong documentation habits, attention to detail, ability to manage multiple workstreams
  • Scrappy, can-do attitude

Skills

Required:SPR/BLI assay development and analysisKinetics modeling and data interpretationSOPs and experimental documentation

Benefits

  • Significant equity ownership
  • 401k
  • Medical insurance and dental insurance
  • Unlimited PTO
  • Weekday lunches and dinners
Last updated Aug 5, 2026. Interested? Apply on the company site.

About Medra

Hand over lab work

Scientists automate protocols with Medra’s autonomous robotic system.

BiochemistryCell BiologyGenomicsHistologyMicrobial discoveryAIRobotics
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