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Research Leader / Senior Scientist (In vitro / Cellular Pharmacology), Cambridge, MA

Isomorphic Labs· DDMR
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Hybrid (Cambridge, MA)Full-timePosted 2mo ago

About the role

Isomorphic Labs is seeking an experienced in vitro/in cellular pharmacology leader to define screening strategies and lead biology within small molecule drug discovery programs, bridging computational predictions and experimental validation in a hybrid work environment.

Responsibilities

  • Design efficient and comprehensive biological screening cascades for internal and partnered drug design programs.
  • Guide the optimization and implementation of biophysical and biochemical assays, including SPR, ITC, and enzymatic methodologies, to evaluate target interaction, pharmacological potency, and molecular specificity.
  • Direct the development and refinement of functional and phenotypic cellular assays to advance target validation and mechanistic understanding.
  • Work with CROs to design decision-making experiments and deliver high-quality biological data to inform path to the clinic.
  • Evaluate, interpret, and synthesize complex binding, kinetic, and dose-response information; generate precise technical documentation to guide strategic decision-making and support IND-enabling data packages.
  • Act as a bridge between computational prediction and experimental reality, collaborating with AI/ML/Data Science, Medicinal Chemistry, Structural Biology, and In vivo Pharmacology/Translational Sciences to align data and drive lead optimization and translational study design.
  • For roles with people management, line manage and mentor a team of 2-3 In vitro / Cellular Pharmacologists, fostering scientific growth and cross-disciplinary collaboration.

Qualifications

  • Ph.D. in Pharmacology, Biochemistry, Cell Biology, Biophysics, or related discipline.
  • 8+ years / 5+ years of professional experience in a Translational Sciences role within biotech, pharma, or CRO settings.
  • Experience leading biology within small molecule drug discovery programs from inception to clinical candidate delivery.
  • Experience leading a high-performing scientific team (for management role).
  • Extensive experience designing and implementing biological screening cascades for drug design projects (hit to candidate).
  • Deep knowledge of in vitro pharmacology techniques including biophysical, biochemical, and/or cellular assays.
  • Ability to provide technical guidance within matrixed organizations and coordinate cross-functional programs.
  • Experience working with CROs to obtain and interpret high-quality biological data in a timely manner.
  • Dynamism and agility across multiple projects and therapeutic areas.
  • Effective communication across interdisciplinary teams.

Skills

Required:In vitro pharmacologyBiophysical assays (SPR, ITC)Cell-based assaysCRO management

Benefits

  • Hybrid working arrangement with in-office three days per week requirement (Tue, Wed, and one other day).
  • Collaborative culture with opportunities to work with world-leading ML and drug discovery experts.
  • Supportive environment for learning, development, and adoption of next-generation tools.
Last updated Aug 12, 2026. Interested? Apply on the company site.

About Isomorphic Labs

Reimagining Drug Discovery Process with AI

Isomorphic Labs is building a future where frontier AI can help to unlock deeper scientific insights, faster breakthroughs, and life-changing medicines.

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