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Research Leader / Senior Scientist (In vivo Pharmacology & Translational Sciences), Cambridge, MA

Isomorphic Labs· DDMR
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Cambridge, MAFull-timePosted 2mo ago

About the role

Senior translational biology roles focused on in vivo pharmacology, translational strategies, and bridging computational predictions with experimental validation to advance ML-designed medicines from early discovery to clinical development.

Responsibilities

  • Oversee planning, methodology development, fiscal management, and implementation of target-specific in vitro and in vivo pharmacology, PK/PD, and safety assessments across project portfolios.
  • Design robust translation strategies geared toward clinical translation using datasets and biomarkers to inform patient selection frameworks.
  • Define model paradigms for translational packages (in vivo, ex vivo patient-derived tissue, etc.) and develop biomarker strategies for early clinical proof of concept.
  • Work with CROs to design decision-making experiments and deliver high-quality biological data to inform path to the clinic.
  • Provide scientific expertise to ML and computational biology teams to support predictive models of biological systems.
  • Distill biological data into actionable insights for project leaders, teams, and partners.
  • Be integrated in or lead projects to provide strategic input for project success.
  • Analyze and interpret experimental data to produce high-quality reports for go/no-go decisions and IND filings.
  • Bridge computational prediction and experimental reality, collaborating with ML/Data Science, Discovery Biology/Lead Optimization, DMPK/Toxicology, Clinical Development/Program Management to translate hypotheses into trial designs and biomarkers.

Qualifications

  • Ph.D. in Pharmacology, Immunology, Cancer Biology, Molecular Biology, or related discipline.
  • 8+ years / 5+ years of professional experience in a Translational Sciences role in biotech/pharma/CRO.
  • Experience in project leadership / leading biology within small molecule drug discovery programs (from inception to clinical candidate delivery).
  • People management experience for a high-performing scientific team (for manager track).
  • Deep understanding of target, mechanism, and disease interdependencies; expertise in translational models in oncology and/or immune disorders.
  • Extensive pharma/biotech experience developing Target Product Profiles (TPPs) and translating them into biological screening cascades.
  • Proven track record in translational data packages and biomarker strategies to inform clinical trial design.
  • Experience designing PK/PD experiments for human dose prediction and coordinating with ADMET, formulation, and clinical teams.
  • Proven experience managing multi-vendor CRO networks (negotiation, timelines, data quality).
  • Exceptional project management and leadership capabilities; ability to influence matrixed teams without direct authority.

Skills

Required:PharmacologyTranslational strategy designModel system selectionCRO management
Last updated Aug 12, 2026. Interested? Apply on the company site.

About Isomorphic Labs

Reimagining Drug Discovery Process with AI

Isomorphic Labs is building a future where frontier AI can help to unlock deeper scientific insights, faster breakthroughs, and life-changing medicines.

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