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Clinical Contracts Manager, Cambridge, MA

Isomorphic Labs· Clinical
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Hybrid (Cambridge, MA)Full-timePosted 2mo ago

About the role

Clinical Contracts Manager acts as the primary contact for vendor outsourcing and business contracting in assigned therapeutic and functional areas, driving vendor selection, negotiating MSAs/CTAs, and managing vendor study budgets and contract lifecycle to ensure compliant and timely trial execution.

Responsibilities

  • Provide primary outsourcing and vendor management support for clinical development functional areas across the portfolio.
  • Independently lead RFI and RFP processes, analyze supplier services, proposals, and budgets, conduct bid defense meetings, and recommend vendor selection for executive decision-making.
  • Negotiate and execute complex vendor agreements and Master Service Agreements (MSAs) with preferential terms and pricing.
  • Define and implement vendor assessment criteria, benchmark metrics, and process improvement initiatives to optimize clinical outsourcing.
  • Drive negotiations for CTAs and investigator budgets directly with clinical sites.
  • Partner with Clinical Trial Managers, program teams, and CROs to ensure vendors deliver against study timelines, quality standards, and budget expectations.
  • Assess and integrate potential AI tools to facilitate and enable contract negotiations and management.
  • Ensure full consistency between contractual agreements and operational trial implementation.
  • Monitor study progress, vendor deliverables, and resource allocation throughout the study lifecycle, supporting teams in final financial reconciliation at study closeout.
  • Actively monitor study progress for scope changes, driving negotiations for change orders and associated costs to minimize sponsor risk.
  • Identify contractual risks, mitigate scope creep, and ensure adherence to FMV standards, legal requirements, and healthcare compliance.
  • Proactively address contractual challenges, develop risk mitigation plans, and facilitate escalation management for leadership review when needed.
  • Participate in vendor oversight and governance meetings, supporting study teams in resolving vendor performance issues.
  • Seek out and assess potential AI solutions that could assist in this space.

Qualifications

  • Bachelor’s degree (BA/BS); degree in Healthcare, Science or Finance preferred.
  • Minimum 5+ years of experience in clinical outsourcing, contracting, procurement, or finance within pharmaceutical, biopharma, CRO, or clinical research setting.
  • In-depth knowledge of clinical trial execution, CRO outsourcing models, and regulatory guidelines (GCP/FDA).
  • Oncology and/or Rare Disease experience required.
  • Ability to independently complete and drive all key responsibilities.
  • Strong contract negotiation, budget management, and project management skills with a track record across multi-project timelines.
  • Excellent written and oral communication skills for internal and external partners.
  • AI-curious mindset with interest in leveraging emerging AI technologies to streamline contract lifecycle management.
  • Strategic and analytical thinker with problem-solving abilities and adaptability in fast-paced environments.
  • Proven ability to build cross-functional relationships, mentor team members, and drive solutions across boundaries.

Skills

Required:Vendor managementRFI/RFP process leadershipContract negotiationBudget managementRegulatory knowledgeCommunication

Benefits

  • Not specified in the description
Last updated Aug 19, 2026. Interested? Apply on the company site.

About Isomorphic Labs

Reimagining Drug Discovery Process with AI

Isomorphic Labs is building a future where frontier AI can help to unlock deeper scientific insights, faster breakthroughs, and life-changing medicines.

AIBiotechnologyDrug DiscoveryPharmaceuticalsliquid-ai-recruiting-target
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