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Associate Director, Translational Medicine, Oncology, Cambridge, MA

Isomorphic Labs· Clinical
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Hybrid (Cambridge, MA)full-timePosted 2mo ago

About the role

Associate Director of Translational Medicine leads and executes the Translational Medicine strategy for Isomorphic Labs’ oncology portfolio, leveraging AI and emerging technologies to inform clinical development and biomarker strategies.

Responsibilities

  • Lead and execute the Translational Medicine strategy across oncology programs. Ensure readiness of clinical biomarker assays and delivery of corresponding data to address mechanism of action, predictive and prognostic insights, mechanisms of drug resistance and to inform future indications and combinations.
  • Serve as a core member of the oncology program teams and subject matter expert for cancer biology. Collaborate with cross-functional teams to set the program strategy and clinical trial design across tumor types and drug modalities.
  • Deliver clinically validated assays and advance companion diagnostic development for biomarker selected studies.
  • Work closely with the early portfolio scientific teams to ensure clinical input is incorporated at the start of the drug development process, and preclinical insights are translated into the clinical design
  • Collaborate with AI and Computational Biology teams to identify, create and utilize innovative tools for analysis of biomarker and translational datasets, accelerate diagnostic advances and explore new approach methodologies (NAMs).
  • Serve as a key contributor to the translational sections of clinical and regulatory documents including INDs, IBs, clinical protocols, lab manuals, and briefing books.
  • Collaborate across internal and external stakeholders to represent and communicate the translational strategy.
  • Oversee and manage external CROs to ensure on time and robust data delivery

Qualifications

  • Ph.D. or similar in biology or related field
  • 7+ years of translational experience within biotech or pharma including oncology.
  • Proven success implementing and executing translational strategy, clinical biomarkers and diagnostic development in oncology studies.
  • Experience working cross-functionally with key stakeholders internally as well as external vendors and collaborators.
  • Significant expertise in cancer biology and drug development
  • Strong appetite to work in an AI-first environment.
  • Willingness to go beyond traditional assays and approaches, incorporating cutting edge methodologies that may enhance therapeutic probability of success and velocity.
  • Sense of urgency and accountability to operate in a fast-paced environment.
  • Flexibility to adapt to changing timelines and priorities.
  • Strong leadership and excellent communication skills.

Skills

Required:Translational Medicine leadershipCancer biologyBiomarker and companion diagnostic developmentRegulatory documentationCross-functional leadership

Benefits

  • Not explicitly listed in the description
Last updated Oct 14, 2026. Interested? Apply on the company site.

About Isomorphic Labs

Reimagining Drug Discovery Process with AI

Isomorphic Labs is building a future where frontier AI can help to unlock deeper scientific insights, faster breakthroughs, and life-changing medicines.

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