Senior Research Associate, In Vitro Screen Execution (Fixed-Term Contract)
Palo Alto, CA$84.3k - $106kcontractPosted 1mo ago
About the role
Senior Research Associate to support execution of arrayed genetic and chemical perturbation screens in disease-relevant 3D neural models as part of Arc Institute’s Alzheimer's Disease Initiative. Fixed-term 12 months, on-site in Palo Alto, 5 days/week.
Responsibilities
- Execute culture, quality control and validation of complex in vitro 3D neural and glial models.
- Support the execution of high throughput arrayed chemical and genetic perturbation screens for the Alzheimer’s Disease Initiative at Arc.
- Leverage in vitro cell-based assays (flow cytometry, imaging, immunostaining, etc.) and molecular biology techniques to characterize the functional effects of genetic and chemically perturbed cells within these models.
- Have a systematic approach to the execution of tasks and experiments with a focus on efficiency and reproducibility.
- Maintain careful records in ELN (electronic lab notebook) and organize materials and reagents with detailed tracking in our LIMS system.
- Collaborate with other teams at Arc to coordinate screening steps and sample transfer.
- Analyze and present experimental data at internal meetings and seminars.
Qualifications
- BS degree in relevant field with 4+ years of relevant experience, or MS degree in relevant field with 2+ years of relevant postgraduate experience
- Substantial experience culturing and maintaining human PSC-derived cell types or organoids (NPCs, neurons, astrocytes, microglia, or similar) with reliable, reproducible results
- Demonstrated ability to execute multiple cell culture protocols with precision and to transition between them accurately, maintaining fidelity to each protocol's specific requirements (workflow, media, and timeline)
- Familiarity with maintaining and tracking complex in vitro co-cultures using assays such as imaging, flow cytometry, qPCR, proteomics and transcriptomics-based readouts
- Excellent aseptic technique and consistent cell-culture practice held to a high, production-type standard
- Meticulous documentation and record-keeping; comfort working to a production schedule, and basic data tracking and analysis
- Work onsite in Palo Alto office 5 days per week; occasional weekend work may be required
Skills
Required:Cell culture of human PSC-derived cell types or organoidsHigh throughput screeningMolecular biology techniquesELN/LIMS documentationData analysis and presentation
Nice to have:Collaboration and cross-functional teamwork
Last updated Oct 14, 2026. Interested? Apply on the company site.
About Arc Institute
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Arc Institute is a nonprofit research organization headquartered in Palo Alto, California.
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