Senior Research Associate, Molecular Engineering (Fixed-Term Contract)
Palo Alto, CA$84.3k - $106kfixed-term, 12-month contractPosted 4d ago
About the role
Senior Research Associate to support routine execution of arrayed and pooled genetic perturbation screens in disease-relevant human pluripotent stem cell-derived microglia, contributing to Alzheimer's Disease Initiative pipelines.
Responsibilities
- Execute routine stem cell culture and differentiation protocols.
- Conduct and optimize medium- to high-throughput lentiviral transduction-based experiments to introduce arrayed genetic perturbations into engineered cell lines.
- Leverage in vitro cell-based assays (flow cytometry, imaging, immunostaining, etc.) and molecular biology techniques to characterize the functional activity of genetically perturbed cells before and after differentiation into relevant cell types.
- Support the cross-functional execution of arrayed and pooled genetic perturbation screens for the Alzheimer’s Disease Initiative at Arc.
- Have a systematic approach to the execution of tasks and experiments with a focus on efficiency and reproducibility.
- Maintain careful records in ELN (electronic lab notebook) and organize materials and reagents with detailed tracking in our LIMS system.
- Troubleshoot and identify opportunities to improve existing protocols and platform capabilities.
- Analyze and present data at internal meetings and seminars
Qualifications
- BS degree in relevant field with 4+ years of relevant experience, or MS degree in relevant field with 2+ years of relevant postgraduate experience.
- Relevant lab experience including demonstrated and proficient skills for stem cell and progenitor cell culturing and routine characterization.
- Experience running and analyzing flow cytometry experiments, including familiarity with running multi-color panels, immunostaining experiments, and FlowJo analyses.
- Experience with LIMS systems, ideally Benchling
- Detail-oriented with excellent organizational and time management skills.
- Strong oral and written communication skills.
- Ability to multitask, willingness to learn, and work in a highly collaborative environment.
- Work onsite in Palo Alto office 5 days per week. Occasional weekend work may be required.
Skills
Required:Stem cell cultureFlow cytometryMolecular biology techniquesLIMS/ELN
Nice to have:CRISPR/Gene editing (preferred)
Benefits
- Not specified in description
Last updated Oct 21, 2026. Interested? Apply on the company site.
About Arc Institute
A full-stack institute for AI and biology research.
Arc Institute is a nonprofit research organization headquartered in Palo Alto, California.
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