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Research Leader (DMPK), Cambridge, MA

Isomorphic Labs· DDMR
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Hybrid (Cambridge, MA)full-timePosted 1mo ago

About the role

Research Leader (DMPK) at Isomorphic Labs Cambridge, leading DMPK strategy for drug discovery projects and advancing AI-first DMPK/PK approaches within a cutting-edge, hybrid-work environment.

Responsibilities

  • Design and implement stage-appropriate DMPK strategies with AI-first approach, integrating quantitative pharmacology and overall project strategies.
  • Design screening cascade and mechanistic experiments to support project progression in a data-driven manner.
  • Integrate DMPK, PD and toxicological data to extract decision-making information, including dose and safety window predictions.
  • Define Quantitative Pharmacology strategy in collaboration with Pharmacology Leads.
  • Optimise the use of Iso’s datasets to address fundamental DMPK questions and advance the field.
  • Optimise molecule design based on physico-chemistry and biotransformation knowledge in collaboration with Chemistry Leads.
  • Maintain knowledge of state-of-the-art technologies and methods to increase confidence in human PK prediction.
  • Author DMPK sections of regulatory documents.
  • Embrace and champion a culture of inclusion and continuous professional development.

Qualifications

  • PhD in either Pharmaceutical Science, Pharmacy, Chemistry, or another relevant subject.
  • 7-10+ years’ professional experience in a DMPK role, operating within a biotech or pharma setting, solving small molecule DMPK-related problems in drug discovery with a track record of delivering high quality candidates.
  • Practical experience developing DMPK and quantitative pharmacology packages to support early clinical development, including authoring and reviewing regulatory documents, ideally in oncology or immunology.
  • Experience of partnering closely with Preclinical and Clinical teams.
  • In depth knowledge of biotransformation.
  • In depth knowledge of PK modelling and scaling of ADME properties.

Skills

Required:DMPK strategy designData integration (DMPK, PD, toxicology)Quantitative PharmacologyRegulatory documentation

Benefits

  • (Not explicitly listed in the provided text)
Last updated Sep 9, 2026. Interested? Apply on the company site.

About Isomorphic Labs

Reimagining Drug Discovery Process with AI

Isomorphic Labs is building a future where frontier AI can help to unlock deeper scientific insights, faster breakthroughs, and life-changing medicines.

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