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Research Leader (Toxicology), Cambridge, MA

Isomorphic Labs· DDMR
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Cambridge, MAfull-timePosted 1mo ago

About the role

Toxicology Lead responsible for developing safety assessment strategy in AI-driven drug discovery, shaping regulatory safety packages, guiding predictive toxicology development, and managing CRO relationships within Isomorphic Labs’ AI-first preclinical platform.

Responsibilities

  • Design and implement safety assessment strategies with an AI-first approach to support small molecules and biologics drug discovery projects.
  • Design screening cascades and mechanistic experiments to support project progression in a data-driven manner.
  • Develop SAR understanding of toxicology main liabilities to optimise chemical and biological matter where needed.
  • Define regulatory safety assessment packages to support successful acceptance by regulatory agencies.
  • Author toxicology sections of regulatory documents.
  • Partner with Machine Learning colleagues to build predictive toxicology aspects of the drug design platform and analyze data to develop predictive models.
  • Identify state-of-the-art technologies and methods to benefit the platform or ways of working.
  • Maintain and develop close relationships with the CRO network to ensure high quality data generation and leverage external expertise.
  • Oversee delivery of data generation campaigns designed to support the development of AI-based toxicology models.
  • Mentor junior team members and promote a culture of inclusion and continuous professional development.

Qualifications

  • Ph.D. in Toxicology, Pharmacology, Biology, or DVM/MD with relevant experience
  • Board Certification
  • Extensive senior toxicology experience across multiple therapy areas in biotech or pharma
  • Demonstrated experience filing successful INDs/CTAs for small molecules and biologics
  • Deep understanding of Global Regulatory Guidelines for safety assessment
  • Experience partnering with Discovery and Clinical teams
  • Excellent written and verbal communication, interpersonal, and influencing skills in cross-functional collaboration
  • Track record of creative problem solving with growth mindset and willingness to learn new concepts

Skills

Required:Toxicology leadershipRegulatory strategyIND/CTA filingsAI in toxicologyCRO managementMentoringCommunication
Last updated Sep 16, 2026. Interested? Apply on the company site.

About Isomorphic Labs

Reimagining Drug Discovery Process with AI

Isomorphic Labs is building a future where frontier AI can help to unlock deeper scientific insights, faster breakthroughs, and life-changing medicines.

AIBiotechnologyDrug DiscoveryPharmaceuticalsliquid-ai-recruiting-target
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