Scientist/Sr. Scientist, Spatial Omics Technology Development (Fixed-Term Contract)
Palo Alto, CA$128.5k - $182.5kfixed-term contractPosted 4w ago
About the role
18-month fixed-term scientist position focused on imaging-based spatial technology development for the Alzheimer's Disease Initiative, including stabilizing a custom imaging platform, adapting homebrew chemistry to arrayed human organoids, and advancing spatial perturb-seq workflows from proof-of-concept to a screen-ready platform for large-scale studies.
Responsibilities
- Design and execute system testing and validation plans for the current custom in-house spatial imaging platform.
- Work directly with external vendors to troubleshoot and resolve hardware and software issues.
- Collaborate with the spatial omics project lead and internal partners to optimize spatial multiomic chemistry and sample-prep workflows for human stem-cell-derived brain organoids, adapting protocols validated in mouse tissue.
- Execute end-to-end wet lab spatial perturb-seq workflows.
- Collaborate with computational scientists to analyze imaging QC data and drive iterative assay development and decision-making.
- Track progress against key milestones and report on progress in internal meetings. Collaborate to move projects from proof-of-concept through development and screens.
Qualifications
- PhD in molecular biology, biochemistry, genomics, bioengineering, or a related field, with 2-5+ years of experience in academia or the biotechnology industry.
- Extensive experience in spatial omics technology and/or product development.
- Hands-on experience with custom imaging and/or fluidic systems, including instrument troubleshooting.
- Hands-on experience with tissue or organoid sample prep and in situ imaging-based assays (e.g., HCR, MERFISH, seqFISH, RCA, in situ sequencing).
- Hands-on experience with tissue microarray or low-input histology is a plus.
- Experience with image processing or spatial data analysis is a plus.
- Background in neuroscience, stem cell biology, or immunology is a plus.
- Comfortable working in a fast-paced, early-stage technology development environment with substantial hands-on troubleshooting.
- Strong collaboration and communication skills across multiple teams.
- Strong project management and documentation skills.
Skills
Required:System testing and validationHardware/software troubleshootingSpatial multiomic workflow optimizationWet lab execution (spatial perturb-seq)
Nice to have:Data analysis (imaging QC)
Last updated Sep 23, 2026. Interested? Apply on the company site.
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