Scientist, Delivery Screening Technology, Horns Lab
Palo Alto, CA$121.3k - $159.5k + bonusfull-timePosted 4w ago
About the role
Scientist to lead development of pooled screening technology for delivery of molecular cargo by biological nanoparticles, building scalable platforms to discover and engineer next-generation delivery vehicles (e.g., virus-like particles, vesicles) and to elucidate principles of cellular delivery.
Responsibilities
- Design, build, and validate molecular reporters that measure how efficiently delivery vehicles enter cells and release cargo
- Design and construct pooled libraries of engineered delivery vehicles and cellular components, and execute screens with sequencing-based readouts
- Scale the platform from proof-of-concept to large multiplexed screens, and apply it to discover and engineer improved delivery vehicles
- Design and execute validation experiments, including orthogonal assays and characterization of individual hits
- Analyze sequencing data computationally, including developing analysis pipelines
- Collaborate with lab members developing complementary screening platforms
- Embrace the opportunity to creatively collaborate with Technology Centers and other laboratories
- Maintain accurate and detailed records of experimental protocols, results, and conclusions
- Present key research findings at internal meetings and seminars, and external conferences
- Provide guidance and mentorship to Research Associates
- Stay updated on advancements in functional genomics, synthetic biology, and drug delivery by reading literature and attending conferences
Qualifications
- PhD in cell or molecular biology, genetics, biochemistry, bioengineering, or a related field with 0-5 years of relevant post-PhD experience in academia and/or industry
- Deep hands-on experience in pooled screening with end-to-end ownership, including library design and construction, screen execution, NGS readout, and hit calling and analysis
- Demonstrated track record of developing and validating novel quantitative molecular assays from scratch, with strong troubleshooting skills
- Fluency with mammalian cell culture and cell engineering, including construct design, cloning, and characterization of genetically modified cells
- Proficiency with flow cytometry, including selection for pooled screens
- Ability to analyze large and complex data sets using Python, R, or similar tools
- Strong quantitative aptitude and rigorous approach to experimental design
- Strong project management skills with the ability to plan, execute, and deliver results on time
- Excellent written and verbal communication skills
- Demonstrated ability to work in a fast-paced environment and be both an independent thinker and a collaborative team player
Skills
Required:Pooled screeningMolecular reporter designMammalian cell culture and cell engineeringFlow cytometryData analysis (Python/R)Project managementCommunication
Benefits
- Base salary range provided: $121,250 to $159,500
- Annual discretionary bonus eligibility
- Compound Cash Grant Program (CCGP) with multi-year cash grants
- Long-term funding and research autonomy typical of Arc Institute environment
Last updated Sep 30, 2026. Interested? Apply on the company site.
About Arc Institute
A full-stack institute for AI and biology research.
Arc Institute is a nonprofit research organization headquartered in Palo Alto, California.
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