← All roles

Senior Systems Engineer

Heartflow· Software Engineering
Apply on company site
Hybrid (SF)$180k - $215kFull-timePosted 2w ago

About the role

Senior Systems Engineer responsible for system-level design, requirements tracing, and cross-functional technical leadership to develop Heartflow’s core medical device software-enabled products.

Responsibilities

  • System Architecture & Requirements: Define system requirements and maintain the functional system architecture: the major subsystems, what each must do, and the interfaces and data flows between them.
  • Traceability: Ensure traceability between user needs, requirements, and their verification and validation (V&V) evidence, and maintain it as the system evolves.
  • System Integration: Identify and resolve complex technical issues across system boundaries, and coordinate dependencies across engineering disciplines.
  • Verification & Validation Strategy: Own the system-level V&V strategy: what must be verified or validated, at what level, and what evidence verifies each requirement. Partner with the System Test and Software Engineering teams to ensure requirements are clear and testable.
  • Risk Management & Reliability: Identify, analyze, and mitigate technical and product risks. Support failure investigations (e.g., CAPAs, NCs), root cause analysis, corrective actions, and assessments of system reliability and performance.
  • Technical Trade-offs: Evaluate and communicate trade-offs involving performance, safety, usability, reliability, scalability, maintainability, schedule, and cost. Use data and engineering judgment to recommend solutions and drive decisions.
  • Cross-Functional Technical Leadership: Serve as the technical lead and coordinate cross-functional technical efforts across software, algorithm, quality, regulatory, clinical, product, and operations teams, from concept development through software release and post-market surveillance.
  • Systems Engineering Practices: Promote and improve systems engineering practices across the organization, including effective requirements management, risk management, verification planning, traceability, and SDLC improvements. Mentor Systems Engineers as the team scales.

Qualifications

  • Education: Bachelor's, Master's, or Ph.D. in Systems Engineering, Computer Science, Biomedical Engineering, or related field.
  • Experience: 8+ years in systems engineering or related engineering role developing complex software-enabled products.
  • Systems Engineering Fundamentals: Experience defining functional system architectures, requirements, specifications, and interfaces.
  • Integration & Troubleshooting: Ability to integrate multidisciplinary systems, analyze complex technical problems, perform root cause analysis, and drive issues to resolution.
  • Verification & Risk: Experience defining system-level verification strategies and reviewing test plans and results for requirement coverage; working knowledge of product risk management and design controls.
  • Software Lifecycle Standards: Working knowledge of IEC 62304 and medical device software lifecycle considerations.
  • Technical Judgment: Ability to balance user needs, safety, performance, reliability, quality, schedule, and cost in recommendations.
  • Cross-Functional Leadership: Ability to lead technical discussions and collaborate across multiple teams.
  • Technical Communication: Strong written and verbal skills to convey complex concepts clearly.
  • Technical Tools: Experience with requirements management, issue tracking, documentation, or product lifecycle management tools (e.g., Jira, Ketryx). Familiarity with Python or similar tools is a plus.

Skills

Required:System architectureRequirements traceabilityVerification & Validation planningRisk managementCross-functional leadershipSystems engineering practices
Nice to have:Regulatory/standards familiarity

Benefits

  • Bonus
  • Equity
Last updated Oct 12, 2026. Interested? Apply on the company site.

About Heartflow

Decisive Coronary Care

Heartflow’s vision is to transform CAD from the leading cause of death into a disease that can be managed for life.

CCTA ResourcesRoadmap AnalysisFFRCT AnalysisPlaque AnalysisHeartflow OneHeartflow One PlatformMeasurable Impact
Company profileWebsite

More open roles at Heartflow