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Principal Software Engineer, App

Lila Sciences· Software
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Hybrid (Cambridge, MA and San Francisco, CA)$204k - $348kFull-timePosted 5mo ago

About the role

Principal Software Engineers to design agents, interfaces, and platform integrations that enable researchers to collaborate with AI within LILA’s AI-native platform.

Responsibilities

  • Design & Build UI and APIs: Design and build high-performance, secure, and well-documented UI and APIs that integrate with AI-driven applications.
  • Database Architecture & Scaling: Develop schemas and manage diverse data systems (SQL, NoSQL, Vector DBs, and others) for optimal performance and scalability.
  • Application Development: Drive the implementation of front-end and backend services, focusing on performance, maintainability, and reliability.
  • Performance & Reliability: Diagnose and optimize system bottlenecks, ensuring high availability and low-latency performance across large-scale workloads.
  • Cloud & Infrastructure: Leverage AWS services, Kubernetes and modern DevOps practices to build and deploy production-grade systems at scale.
  • Cross-Functional Collaboration: Work with ML researchers, engineers, and scientists to integrate data pipelines, APIs, and cloud infrastructure into scientific workflows.

Qualifications

  • Bachelor’s or Master’s degree in Computer Science, Engineering, or related field.
  • 8-15 years of engineering experience building and deploying large-scale systems in production. You must be strong in either front-end or backend.
  • Full Stack Development: Experience developing web apps across the full stack (React, TypeScript, Monorepos like Nx, TailWind, FastAPI, SQL/NoSQL, Python, Pydantic).
  • Hands on experience using AI coding assistants to drive productivity is required.
  • Communication & Collaboration: Acute listening skills, and a proven track record of working cross-functionally with scientists, data engineers, and product teams; able to explain complex ideas to diverse audiences.
  • Problem Solving: Proven ability to take ownership of complex backend challenges, balancing trade-offs between scalability, performance, and maintainability.

Skills

Required:UI & API DesignDatabase ArchitectureFull Stack DevelopmentAI Coding AssistantsCommunication & CollaborationProblem Solving

Benefits

  • Full-time U.S. benefits including medical, dental, and vision; employer-paid life and disability; flexible time off with holidays; paid parental leave; educational assistance; commuter benefits (bike share); subsidized lunch.
  • International benefits tailored to region; USD salary ranges apply only to U.S.-based positions; international salaries set to local market.
Last updated Oct 21, 2026. Interested? Apply on the company site.
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About Lila Sciences

Pioneering Scientific Superintelligence

Pioneering Scientific Superintelligence to solve humankind’s greatest challenges.

Scientific SuperintelligenceAIAutonomous LabsLife SciencesChemical SciencesMaterials Sciences
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