Director, Office of the CEO, Founder in Residence Program
About the role
Director leading the Founder in Residence Program, reporting to the VP of Business Operations and Chief of Staff, with CEO sponsorship. Hybrid onsite 3 days/week in Menlo Park, CA. 12 to 18 month program to work on high-priority strategic and operational projects directly with the CEO and Chief of Staff, with potential to graduate into a permanent Director or Senior Director operating role.
Responsibilities
- Own CEO-Priority Projects: Lead one or more of BillionToOne's highest-priority strategic and operational initiatives each quarter, sourced directly from the CEO and Office of the CEO. Project types span new product launch support, commercial and go-to-market strategy, business development, operational excellence, competitive response, and the incubation of new business lines.
- Find Broken Things and Fix Them: Identify under-performing processes, workflows, or functions. Diagnose root cause, design the fix, and drive execution end-to-end with cross-functional teams.
- Cross-Functional Leadership: Lead and influence cross-functional teams across Sales, Product, Lab Operations, Compliance, Reimbursement, Finance, BD, Legal, and HR. Build deep working knowledge of how each function operates through the projects you lead.
- Operate with AI: Drive results in ambiguous, fast-moving environments. Use first-principles thinking and AI-native fluency to move faster than the company would otherwise be able to.
- CEO and Executive Partnership: Participate in CEO meetings, present to the executive team on an ongoing basis, and serve as a trusted thought partner to the CEO and Chief of Staff on company-shaping decisions.
Qualifications
- 6-10+ years of building or operating experience, with a track record of exceptional impact in entrepreneurial or builder-oriented environments
- One of the following backgrounds: founder of a company that has since been acquired, wound down, or moved on from; senior executive (COO, CPO, VP-level) who joined a top scaleup as one of its first 5 to 10 employees; or top-tier management consultant from MBB or a top boutique firm with healthcare or life sciences exposure, with some operational experience under your belt
- First-principles thinker with exceptional analytical horsepower
- Builder mentality — bias to action, comfort with ambiguity, ability to operate without a playbook
- AI-native fluency in using AI tools to move faster and amplify individual leverage
- Strong written and verbal communication, including with executives and the Board
- Genuine interest in molecular diagnostics and the BillionToOne mission
- On-site position (relocation to SF Bay Area required)
Skills
Benefits
- Working alongside brilliant, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
- Open, transparent culture that includes weekly Town Hall meetings
- The ability to indirectly or directly change the lives of hundreds of thousands of patients
- Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
- Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
- Supplemental fertility benefits coverage
- Retirement savings program including a 4% Company match
- Increased paid time off with increased tenure
- Latest and greatest hardware (laptop, lab equipment, facilities)
- Free daily on-site lunches provided from top eateries
- A variety of perks on campus (state of the art gym, restaurant)
- Free on-site EV charging (compatible with all EVs, including Tesla)

About BillionToOne
The genetic testing platform detecting and measuring disease.
BillionToOne has developed a DNA molecular counter that increases the cell-free DNA diagnostics resolution by over 1,000 fold, which unlocks transformative improvements in prenatal screening and liquid biopsy for cancers. Unity Screen, BillionToOne's commercially available non-invasive prenatal test (NIPT), is the only NIPT that can assess fetal risk for both recessive conditions and aneuploidies from maternal blood. UNITY Screen continues to grow exponentially and is on its path to becoming the next standard-of-care, with an increasing number of publications showing its accuracy and advantages over other screening methods. We have also recently used our molecular counting technology to develop liquid biopsy tests, which have the potential to completely transform oncology care.
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