Associate Scientist III, Cardiac Modeling
insitro· Therapeutic Areas
South San Francisco, CA$107k - $114kFull-timePosted 1mo ago
About the role
Associate Scientist III to support iPSC-derived cardiomyocyte models for studying cardiovascular disease, bridging human stem cell biology, cardiac physiology, and scalable experimental platforms to generate datasets for ML-driven drug discovery.
Responsibilities
- Differentiation & QC: Generate and maintain iPSC lines and differentiate into cardiomyocytes in 2D, with quality control and scalability considerations
- Genetic Disease Models: Build isogenic iPSC-CM disease models including patient and CRISPR-edited lines and characterize cellular models
- Functional Readouts: Develop and optimize functional assays relevant to cardiovascular disease (contractility, electrophysiology, calcium handling, stress responses, high-content imaging) for high-throughput data acquisition
- Rigor & Reproducibility: Document procedures, SOPs, present results, and maintain lab notebook with scientific rigor
- Target Identification: Contribute to target identification and validation by linking cellular phenotypes to human genetic evidence
Qualifications
- Bachelor’s or Master’s degree in biology, biochemistry, or related discipline with at least 2 years of biotech/biopharma experience
- Hands-on iPSC culture, cardiac-directed differentiation and iPSC-CM characterization in 2D; experience with 3D/engineered heart tissue or organoids is a plus
- Experience developing genetic iPSC-CM disease models (patient-derived lines, CRISPR-edited isogenic pairs)
- Background in cardiomyocyte biology and/or cardiovascular disease (preferred)
- Experience with functional assays relevant to cardiomyocyte biology (contractility, calcium, electrophysiology, imaging, stress responses); HT or automated systems a plus
- Molecular assays experience (PCR, RT-qPCR, Western Blot, immunofluorescence)
- Strong scientific communication skills and track record of rigorous experimentation
Skills
Required:iPSC cultureiPSC-CM model characterizationGenetic disease modelingFunctional assays (contractility, electrophysiology, calcium handling)Molecular assays (PCR, RT-qPCR, Western Blot, immunofluorescence)Scientific communication
Benefits
- Annual Performance Bonus Plan eligibility
- Equity Incentive Plan eligibility
- 401(k) with employer matching
- Medical, dental, vision, and mental health support
- Open, flexible vacation policy
- Paid parental leave (at least 16 weeks for birth; 10 weeks for new parent)
- Quarterly budget for books and online courses
- New hire home office setup stipend
- Monthly cell phone & internet stipend
- Free onsite baristas and daily lunch for onsite/hybrid employees
- Free commuter bus network to South San Francisco HQ
Last updated Sep 17, 2026. Interested? Apply on the company site.
About insitro
Making Medicines Differently
At insitro, we are building a different kind of drug company to bring better drugs faster to the patients who can benefit most. Through the power of machine learning (ML) and data at scale, we decode the complexities of biology to unlock transformative new medicines.
PipelinePlatformPeoplePublications & PressML-driven platformdrug discoveryneurosciencemetabolism
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