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Principal Software Engineer

Natera· Platform
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Hybrid (South San Francisco, CA)$219.8k - $274.7k + equityFull-timePosted 4mo ago

About the role

Senior technical role owning architecture, implementation, and delivery of major platform initiatives in Natera's R&D cloud/AI-enabled infrastructure, reporting to team lead; involves mentoring, cross-functional collaboration with bioinformaticians and scientists, and development of AI-native tooling.

Responsibilities

  • Architecture & Delivery: Own the design, implementation, and delivery of major initiatives across our platform. Take fuzzy problems through to shipped, working software used in production.
  • Technical Leadership: Lead architecture and design reviews. Help the team find the right solution for the problem and avoid unnecessary complexity. Influence technical decisions across the team.
  • Mentorship: Mentor mid-level engineers through code review, design docs, and pairing. Raise the engineering bar by example.
  • AI-Native Development: Build and improve our AI-coding tooling alongside the rest of the team. Help us push the frontier of agent-driven software development inside the company.
  • Cross-Functional Partnership: Work with bioinformaticians, scientists, and other R&D engineers to understand their needs and translate them into platform capabilities. Partner with the team lead on roadmap, prioritization, and tough technical calls.

Qualifications

  • 10+ years of professional software engineering experience across a range of systems and problem types.
  • Production experience with a major cloud platform (AWS preferred; GCP or Azure equivalent). You've designed for a cloud, not just deployed to one.
  • Production experience with Kubernetes (or equivalent). Comfortable reasoning about cluster design, scheduling, networking, and workload patterns.
  • Production experience with Terraform (or equivalent). Comfortable owning shared modules and multi-environment deployments.
  • Strong proficiency in at least one general-purpose language (Python, Go, Java, or similar). Comfortable picking up new languages as needed — and comfortable using AI tooling to accelerate that.
  • You've shipped software to end users (internal or external). You understand the realities of running a product.
  • You've led an engineering team before and have mentored junior engineers. Comfortable being the technical owner of multi-quarter initiatives.
  • You've worked in fast-moving environments where results need to be delivered quickly. Scrappy, MVP-first, shipping in days rather than weeks.
  • Familiarity with our tech stack: AWS, Kubernetes, Python, Go, Groovy, Terraform, Helm, Nextflow, WDL, Django, React.

Skills

Required:Cloud infrastructure designKubernetesTerraformProgramming languagesEnd-user softwareTeam leadership

Benefits

  • Annual performance incentive bonus
  • Long-term equity awards
  • Comprehensive health benefits (medical, dental, vision)
  • 401(k) with company match
  • Generous paid time off and company holidays
  • Additional wellness and work-life benefits
Last updated Oct 15, 2026. Interested? Apply on the company site.

About Natera

A global leader in cfDNA testing

Dedicated to oncology, women’s health, and organ health. Natera’s cell-free DNA tests help protect health and inform more personalized decisions about care.

oncologywomen's healthorgan healthcell-free DNA
Company profileWebsite

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