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Scientist R&D – Immunohistochemistry (IHC) & Histology

Natera· Bio Development
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Hybrid (San Carlos, CA)$125k - $140kfull-timePosted 3w ago

About the role

Scientist, R&D focused on development, optimization, verification, and validation of IHC and tissue-based workflows to support oncology products and clinical assay development.

Responsibilities

  • Design and execute development, optimization, verification, and validation studies for IHC, histology, and tissue-based workflows.
  • Develop and optimize IHC assays, including antibody selection and titration, antigen retrieval, staining conditions, controls, and assay performance assessment.
  • Evaluate and optimize histology and pre-analytical variables, including tissue fixation, FFPE processing, embedding, sectioning, H&E staining, and slide preparation.
  • Develop and troubleshoot workflows on automated IHC/ISH staining platforms and investigate staining artifacts, reagent performance, tissue quality, and assay variability.
  • Plan and execute moderate- to high-complexity experiments; analyze and interpret results using tools such as Excel, JMP, and image-analysis approaches.
  • Collaborate with Pathology, Clinical Laboratory Operations, Quality, Automation, and other cross-functional teams to transfer R&D methods into robust clinical laboratory workflows.
  • Author study protocols, development/validation reports, SOPs, and transfer documentation, and provide technical guidance and training during implementation.
  • Communicate project progress, experimental findings, risks, and recommendations to project teams and stakeholders.

Qualifications

  • Ph.D. in Pathology, Cancer Biology, Molecular Biology, Cell Biology, Biomedical Sciences, or a related field with a minimum of 2 years of relevant industry experience; or a Master's degree with a minimum of 5 years of relevant industry experience; or a Bachelor's degree with a 6-8+ years of relevant industry experience.

Skills

Required:IHC assay developmentAntibody characterization/titrationExperiment design and data interpretationTechnical writing and collaboration
Nice to have:Automated IHC/ISH platformsHistology/digital pathology/image analysisNGS and molecular biology workflowsRegulated clinical laboratory experience

Benefits

  • Competitive Benefits - medical, dental, vision, life and disability plans for eligible employees and dependents; free testing for employees and immediate families; fertility care benefits.
  • pregnancy and baby bonding leave
  • 401k benefits
  • commuter benefits
  • employee referral program
Last updated Oct 22, 2026. Interested? Apply on the company site.

About Natera

A global leader in cfDNA testing

Dedicated to oncology, women’s health, and organ health. Natera’s cell-free DNA tests help protect health and inform more personalized decisions about care.

oncologywomen's healthorgan healthcell-free DNA
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