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Director of Bioinformatics and Machine Learning

Natera· Molecular Biology Informatics & Statistics
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San Carlos, CA$228.6k - $285.8k + equity + bonusFull-timePosted 5d ago

About the role

Lead technology and biomarker research for cancer early detection programs by heading a team of bioinformatics and machine learning scientists focused on cfDNA assays across MCED, tfMRD, and single-cancer screening; translate research into clinical diagnostics while guiding technical direction and prototyping.

Responsibilities

  • Define and execute research roadmaps for cancer early detection in partnership with Research, Product, Clinical, and Assay Development stakeholders.
  • Lead, hire, and develop a team of machine learning and bioinformatics scientists, building a culture of scientific rigor, innovation, and ownership.
  • Own the computational design of research studies, including cohort selection, confounder control, and validation strategies that prevent overfitting and data leakage.
  • Partner with molecular biology teams to design experiments that generate data capable of answering the key scientific and clinical questions.
  • Serve as the computational subject matter expert for leadership and cross-functional partners, communicating tradeoffs, risks, and recommendations clearly to technical and non-technical audiences.
  • Advance Natera's scientific leadership through publications, conference presentations, and intellectual property.

Qualifications

  • PhD in Bioinformatics, Computer Science, Statistics, or a related quantitative field.
  • 10+ years of post-PhD experience in industry or academic research, including 5+ years of direct people management leading technical teams of 5 or more scientists.
  • Demonstrated track record of developing and deploying machine learning and statistical models on high-throughput sequencing data.
  • Deep understanding of next-generation sequencing (NGS) data and large-scale genomic datasets, including sources of technical bias and batch effects.
  • Strong communication skills, with experience influencing scientific direction at a senior level.

Skills

Required:PhD-level domain expertise in bioinformatics or related fieldMachine learning and statistical modeling on sequencing dataNGS data and large-scale genomic datasets

Benefits

  • Annual performance incentive bonus
  • Long-term equity awards
  • Comprehensive health benefits (medical, dental, vision)
  • 401(k) with company match
  • Generous paid time off and company holidays
  • Additional wellness and work-life benefits
Last updated Oct 22, 2026. Interested? Apply on the company site.

About Natera

A global leader in cfDNA testing

Dedicated to oncology, women’s health, and organ health. Natera’s cell-free DNA tests help protect health and inform more personalized decisions about care.

oncologywomen's healthorgan healthcell-free DNA
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