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Principal/Senior Scientist, Translational Biomarkers

NewLimit· Single Cell Technology
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South San Francisco, CA$155k - $200kFull-timePosted 6mo ago

About the role

Senior/Principal Scientist leading discovery, development, and qualification of pharmacodynamic biomarker assays to characterize biological activity of mRNA-LNP medicines in preclinical and IND-enabling studies; technical leader shaping PD biomarker strategy from discovery to qualification and clinical milestones.

Responsibilities

  • Discover pharmacodynamic biomarkers to support the clinical development of drugs across multiple programs
  • Own the design, development, and qualification of PD biomarker assays across various platforms to support preclinical studies
  • Define go/no-go criteria for biomarker advancement and contribute to the PD biomarker strategy in regulatory submissions
  • Drive data analysis, interpretation, and reporting for bioanalytical studies
  • Contribute to sample processing workflows including tissue harvesting, primary cell culture, and complex matrix handling
  • Mentor research associates, establish SOPs, and build institutional knowledge within the bioanalytical function

Qualifications

  • PhD in molecular biology, biochemistry, cell biology, or a related field or equivalent industry experience (5+ years)
  • 3+ years of hands-on experience in various quantitative bioanalytical assay platforms (e.g., RT-qPCR, ddPCR, ELISA, MSD, Olink, SOMAscan, NGS-based methods) in complex biological matrices (serum, plasma, tissue homogenates)
  • Strong working knowledge of bioanalytical method qualification/validation principles for PD biomarker measurements, including familiarity with ICH M10 guidelines and fit-for-purpose frameworks
  • History of delivering results for bioanalytical projects -- discovered a PD biomarker or built an assay and solved problems
  • Experience with primary cell culture and tissue-derived sample workflows

Skills

Required:Pharmacodynamic biomarker discovery and developmentBioanalytical assay developmentPrimary cell culture and tissue workflows

Benefits

  • Comprehensive Health, Dental, and Vision insurance
  • 401(k) plan with company match
  • Paid parental leave
  • Industry-leading PTO: 20 days per year plus holidays
  • On-site meals and snacks
Last updated Oct 8, 2026. Interested? Apply on the company site.

About NewLimit

Extending human healthspan

NewLimit is extending human healthspan by unlocking regenerative potential.

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