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Scientist- Delivery Sciences-targeted LNPs (tLNPs)

NewLimit· Delivery Sciences
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South San Francisco$130k - $171kFull-timePosted 1w ago

About the role

Scientist to design, formulate and characterize targeted LNPs (tLNPs) with antibody conjugates, Nanobodies, and scFv’s to enable extra-hepatic delivery of nucleic acid payloads. Hands-on bench role focusing on design, conjugation, testing, and optimization of tLNPs with SAR-driven development.

Responsibilities

  • Design and develop LNP compositions and conjugation chemistries for antibodies, nanobodies, scFv’s, peptides, and other targeting moieties across multiple structural families, pushing beyond current-generation materials for extra-hepatic targeting.
  • Plan conjugation reactions and purification for these modalities with scale and final purity in mind from the outset, delivering against agreed project timelines.
  • Test targeting lipids for the tLNP platform using an SAR-based approach to guide the next design cycle.
  • Develop conjugation chemistries in-house or collaborate with external partners to obtain targeted LNPs for specific target cells and build processes to support testing in vivo.
  • Turn in vitro and in vivo data from discovery teams into concrete structural hypotheses and optimize tLNP compositions or targeting moieties used.
  • Present experimental results and SAR conclusions, authoring protocols and technical reports.

Qualifications

  • PhD in Pharmaceutical Sciences, Pharmaceutical Chemistry and Biochemistry or related discipline with 1–2 years of relevant work; or an MS with 5 years of focused tLNP design experience for liposomal or lipid nanoparticle applications.

Skills

Required:LNP/tLNP design and formulationConjugation chemistrySAR-driven design and data interpretationPurification techniquesAnalytical characterization

Benefits

  • Comprehensive Health, Dental, and Vision insurance.
  • 401(k) plan with company match.
  • Paid parental leave.
  • Industry-leading PTO: 20 days per year plus holidays.
  • On-site meals and snacks.
Last updated Oct 15, 2026. Interested? Apply on the company site.

About NewLimit

Extending human healthspan

NewLimit is extending human healthspan by unlocking regenerative potential.

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