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Scientist, mRNA Analytical Development

NewLimit· Technical Operations
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South San Francisco, CA$120k - $155kfull-timePosted 4d ago

About the role

Scientist to establish and grow NewLimit's mRNA analytical testing suite, leading development of analytical methods to characterize DNA templates and mRNAs, and driving mRNA process development toward the clinic.

Responsibilities

  • Build the analytical suite
  • Develop and establish analytical methods for DNA template and mRNA drug substance release and characterization
  • Lead studies to evaluate method robustness, specificity, sensitivity, precision, accuracy, and linearity, and set phase-appropriate performance criteria
  • Act as the mRNA analytical lead for CMC program teams
  • Evaluate emerging analytical technologies to expand our internal testing capabilities
  • Run and maintain the assays
  • Perform routine testing of DNA templates and mRNA materials to support process development and research programs
  • Investigate unexpected impurities, degradation, and atypical results
  • Maintain instruments, reference standards, assay controls, and critical reagents
  • Documentation and collaboration
  • Author method protocols and technical development reports
  • Support method transfer and qualification at CDMOs
  • Present experiment results at team meetings
  • Manage the outsourcing of advanced analytical techniques to CROs, as needed

Qualifications

  • Ph.D. in analytical chemistry, biochemistry, molecular biology, chemical engineering, or a related field with 0–3 years of relevant industry experience, or an M.S. with 5+ years or B.S. with 7+ years of relevant industry experience
  • Experience with assay development and qualification across a broad range of mRNA analytical methods
  • Hands-on experience executing and troubleshooting HPLC separations (e.g., IP-RP-HPLC, SEC), capillary electrophoresis, and plate based assays for impurity quantification (e.g. qPCR, ELISA)
  • Ability to independently design, execute, and troubleshoot experiments
  • Ability to analyze and present complex data sets
  • Strong technical writing skills
  • Excellent communication and organizational skills

Skills

Required:Analytical method developmentHPLCCapillary electrophoresisqPCR/ELISAData analysis

Benefits

  • Health, dental, and vision insurance
  • 401(k) with company match
  • Paid parental leave
  • Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
  • Meals and snacks on-site
Last updated Oct 22, 2026. Interested? Apply on the company site.

About NewLimit

Extending human healthspan

NewLimit is extending human healthspan by unlocking regenerative potential.

reprogrammingepigeneticsmedicineaginglongevity
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