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Scientist, mRNA Downstream Purification

NewLimit· Technical Operations
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South San Francisco, CA$120k - $155kfull-timePosted 4d ago

About the role

Scientist to lead downstream process development for the mRNA Engineering team, designing, optimizing, and scaling purification processes for mRNA drug substance in a hands-on, lab-based role spanning program process development and platform engineering.

Responsibilities

  • Develop downstream purification processes: design, execute, and analyze process development studies for mRNA purification
  • Act as the downstream lead for CMC program teams
  • Design and implement automated downstream workflows for high-throughput purification of research-grade mRNA
  • Support execution of research-grade mRNA production runs for discovery and preclinical studies, as needed
  • Support process scale-up from bench to pilot scale, as needed
  • Evaluate emerging purification technologies and chromatography resins
  • Support tech transfer and CDMO manufacturing: perform tech transfer of downstream processes to CDMOs
  • Act as person in plant during CDMO manufacturing runs
  • Support process troubleshooting and deviation investigations at CDMOs
  • Documentation and collaboration: maintain organized experimental records in Electronic Lab Notebooks
  • Author development SOPs and technical development reports
  • Present experiment results at team meetings

Qualifications

  • Ph.D. in analytical chemistry, biochemistry, molecular biology, chemical engineering, or a related field with 0–3 years of relevant industry experience, or an M.S. with 5+ years or B.S. with 7+ years of relevant industry experience
  • Hands-on experience developing downstream purification processes for nucleic acids or other biologics
  • Hands-on experience with tangential flow filtration (TFF)
  • Experience operating ÄKTA chromatography systems
  • Ability to independently design, execute, and troubleshoot experiments
  • Ability to analyze and present complex data sets
  • Strong technical writing skills
  • Excellent communication and organizational skills

Skills

Required:Downstream purification process developmentTangential Flow Filtration (TFF)ÄKTA chromatography systemsExperimental design and troubleshootingData analysis and presentationTechnical writing

Benefits

  • Health, dental, and vision insurance
  • 401(k) with company match
  • Paid parental leave
  • Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
  • Meals and snacks on-site
Last updated Oct 22, 2026. Interested? Apply on the company site.

About NewLimit

Extending human healthspan

NewLimit is extending human healthspan by unlocking regenerative potential.

reprogrammingepigeneticsmedicineaginglongevity
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