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Scientist, Metabolism

NewLimit· Metabolism
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South San Francisco, CA$130k - $165kFull-timePosted 3w ago

About the role

Scientist with experience in liver biology and metabolism to join NewLimit's Metabolism team, focusing on reprogramming medicines to restore youthful function in aged hepatocytes within metabolic disease contexts.

Responsibilities

  • Collaborate with Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes
  • Develop assays to preclinical models of liver disease to measure hepatocyte function
  • Evaluate epigenetic reprogramming payloads using in vivo functional assays to select therapeutic candidates
  • Deliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods (e.g. viral vectors, lipid nanoparticles)
  • Analyze and interpret experimental data to drive pre-clinical decision making

Qualifications

  • Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
  • Experience with primary liver cell isolation and functional characterization
  • Experience working with mouse models of liver dysfunction
  • Experience with transgenic manipulation of liver cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)
  • Exceptional organizational skills, including detailed experimental record-keeping and the ability to manage multiple concurrent project

Skills

Required:Liver biology and metabolismPrimary liver cell isolationIn vivo mouse modelsTransgenic manipulationEpigenetic reprogramming

Benefits

  • Health, dental, and vision insurance
  • 401(k) with company match
  • Paid parental leave
  • Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
  • Meals and snacks on-site
Last updated Oct 1, 2026. Interested? Apply on the company site.

About NewLimit

Extending human healthspan

NewLimit is extending human healthspan by unlocking regenerative potential.

reprogrammingepigeneticsmedicineaginglongevity
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